International Journal of Environmental Sciences

Volume 2 Issue 3 2012           Pages:1596- 1604

Role of non-enzymatic antioxidants in stimulation of Metallothionein against metal toxicity

Author Information:

Dharmendra Kumar- Toxicology Lab, Dept. of Zoology, Govt. P.G. College, Lohaghat -262524, (Champawat), Uttarakhand, India.

ABSTRACT
Metallothionein (MT) is a low molecular-weight protein considered to be protective in function. It has been estimated in the liver and kidney of cadmium, mercury, copper and zinc treated rats offered antioxidative protection by selenium (Se), vitamin E and glutathione (GSH). These antioxidants stimulated induction of MT in liver and kidney of metal treated rats. Induction was greater in liver than kidney.  α -tocopherol induced maximum synthesis of MT in the liver of mercury treated rats during lipid peroxidation, whereas maximum induction of MT in Cd fed rats was observed after GSH treatment. Minimum accumulation of mercury in comparison to other metals was observed in liver as well as kidney in glutathione treated rats.  It is suggested that different metal species induced specific metallothionein(s) that express specific effects. The mechanism for maintaining high levels of MT might result from increased translation and transcription of MT. Present results suggest that these proteins not only scavenge free radicals (FR) but also decrease accumulation of metals in soft tissue. 

Keywords : Metallothionein (MT), Glutathione (GSH), α –Tocopherol (Vitamin E), Selenium (Se), Cadmium (Cd), Mercury (Hg), Copper (Co), Zinc (Zn).

DOI: 10.6088/ijes.00202030044


© 2012 Copyright Dharmendra Kumar, licensee IPA.This is an open access article distributed under the Creative Commons Attribution License (2.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The electronic version of the article can be downloaded below.

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